陈雯雯
发布人:信息发布员  发布时间:2019-11-15   浏览次数:710



1. 个人简介:

陈雯雯 博士,副研究员有机化学专业2003年于华东师范大学化学系获理学学士学位,2008年于中国科学院上海有机化学研究所获理学博士学位,此后分别于加拿大麦吉尔大学化学系和美国伊利诺伊大学芝加哥分校药学院从事两站博士后研究工作,2014年进入中国科学院上海药物研究所工作,2019年加入上海师范大学。近年已在核心期刊Org. Lett.,Org. Chem. Front.,J. Org. Chem.等国际学术杂志上发表学术论文23篇,累计总影响因子大于100,论文被引用600余次已申请国家专利7项,其中3 项已获得授权

教育经历:

2003-2008,博士,中国科学院上海有机化学研究所

1999-2003学士,华东师范大学

工作经历:

2019-至今,上海师范大学  副研究员

2014-2019中国科学院上海药物研究所   副研究员

2009-2012美国伊利诺伊大学芝加哥分校   博士后

2008-2009加拿大麦吉尔大学   博士后

2. 主要研究方向:

[1] 羰基催化模式下的仿生不对称催化反应研究

[2] 手性超强酸的不对称反应研究

[3] 重要有机分子及药物分子合成为导向的碳氢键官能团化反应研究

3. 代表性科研项目:

[1] 基于交叉脱氢偶联策略的生物活性杂环分子的高效合成研究上海市自然科学基金面上项目2018-2021

[2] 具有抗阿尔茨海默症(AD)活性的高选择性GSK-3β抑制剂的设计、合成与应用研究,国家自然科学基金青年基金,2015-2017

4.代表性论文

[1]Gu, C.-X.;Chen, W.-W.*; Xu, B.; Xu, M.-H.* “Synthesis of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones via microwave-assisted base-free intramolecular cross dehydrogenativecoupling”,Tetrahedron 201975, 1605-1611.

[2] Liu,J.-G.;Chen, W.-W.*; Gu, C.-X.; Xu, B.*; Xu, M.-H.*“Access to spiroindolines and spirodihydrobenzofurans via Pd-catalyzed domino Heck spiroyclization through C−H activation andcarbene Insertion”, Org. Lett. 2018, 20, 2728-2732.

[3] Liu, M.-Q.; Jiang, T.;Chen, W.-W.*; Xu, M.-H.*“Highly enantioselective Rh(I)/chiral sulfur-olefin-catalyzed arylation of alkyl-substituted cyclic N-sulfonyl ketimines”,Org. Chem. Front.2017, 4, 2159-2162.

[4] Chen, W.-W.; Xu, M.-H.* “Recent advances in rhodium-catalyzed asymmetric synthesis of heterocycles”,Org. Biomol. Chem.2017,15,1029-1050.

[5] Cheng, C.; Chen, W.-W.*; Xu, B.; Xu, M.-H.* “Access to Indole-Fused Polyheterocycles via Pd-Catalyzed Base-Free Intramolecular Cross Dehydrogenative Coupling”, J. Org. Chem.2016, 81, 11501-11507.

[6] Cheng, C.; Chen, W.-W.*; Xu, B.; Xu, M.-H.*Intramolecular cross dehydrogenative coupling of 4-substituted coumarins: rapid and efficient access to coumestans and indole[3,2-c]coumarins”, Org. Chem. Front. 2016, 3, 1111-1115. (Co-corresponding author)

[7] Wang, Z.; Chen, W.-W.; Xu, M.-H.*“Rhodium-catalyzed Asymmetric Arylation of Nitroalkenes Powered by Simple Chiral Sulfur-Olefin Ligands”, J. Chin. Chem. Soc.2018,65, 331-336.

[8] Jiang, T.; Chen, W.-W.; Xu, M.-H.* “Highly Enantioselective Arylation of N,N-Dimethylsulfamoyl-Protected Aldimines Using Simple Sulfur–Olefin Ligands: Access to Solifenacin and (S)-(+)-Cryptostyline II”, Org. Lett.2017, 19, 2138-2141.

[9] Zhang, Z.-F.;Zhu, D.-X.;Chen, W.-W.; Xu, B.*; Xu, M.-H.*“Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis”,Org. Lett. 2017,19, 2726-2729.

[10] Zhang, Y.-F.; Chen, D.; Chen, W.-W.; Xu, M.-H.* “Construction of Cyclic Sulfamidates Bearing Two gem-Diaryl Stereocenters through a Rhodium-Catalyzed Stepwise Asymmetric Arylation Protocol”, Org. Lett. 2016, 18, 2726-2729.

[11] Zhu, D.-X.; Chen, W.-W.; Xu, M.-H.* “Rhodium-catalyzed asymmetric intramolecular addition of arylboronic acids to ketones: catalytic enantioselective access to 3-hydroxy-2,3-dihydrobenzofurans bearing a tetrasubstituted carbon stereocenter”, Tetrahedron2016, 72, 2637-2642.

[12] Wang, T.-J.; Chen, W.-W.; Li, Y.; Xu, M.-H.* “Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol”, Org. Biomol. Chem.2015, 13, 6580-6586.

[13] Chen, J.-P.; Chen, W.-W.; Li, Y.; Xu, M.-H.* “A highly diastereoselective Friedel-Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles”, Org. Biomol. Chem.2015, 13, 3363-3370.

[14]Chen, W.-W.; Gaisina, I. N.; Gunosewoyo, H.; Malekiani, S. A.; Hanania, T.; Kozikowski, A. P.* “Structure-Guided Design of a Highly Selective Glycogen Synthase Kinase-3β Inhibitor: a Superior NeuroprotectivePyrazolone Showing Antimania Effects”, ChemMedChem 2011, 6, 1587-1592.

[15] Zhou, J.; Zhao, Q.; Chen, W.-W.; Wang, H.; Lin, G.-Q.*; Xu, M.-H.*; Guo, Y.* “Studies on gas-phase cyclometalations of [ArNi(PPh3)n]+ (n = 1 or 2) by electrospray ionization tandem mass spectrometry”, J. Am. Soc. Mass Spectrom. 2010, 21, 1265-1274.

[16] Chen, W.-W.; Zhao, Q.; Xu, M.-H.*; Lin, G.-Q.* “Nickel-Catalyzed Asymmetric Ullmann Coupling for the Synthesis of Axially Chiral Tetra-ortho-Substituted Biaryl Dials”, Org. Lett. 2010, 12, 1072-1075.

[17] Zeng, T.; Chen, W.-W.; Cirtiu, C. M.; Moores, A.; Song, G.; Li, C.-J.* “Fe3O4 nanoparticles, a robust and magnetically recoverable catalyst for three-component coupling of aldehyde, alkyne and amine”, Green Chem. 201012, 570-573.

[18] Chen, W.-W.; Bi, H.-P.; Li, C.-J.* “The first cobalt-catalyzed transformation of alkynyl C-H bond: aldehyde-alkyne-amine (A3) coupling”, Synlett 2010, 475-479.

[19] Bi, H.-P; Teng, Q.; Guan, M.; Chen, W.-W.; Liang, Y.-M.; Yao, X.; Li, C.-J.* “Aldehyde- and ketone-induced tandem decarboxylation-coupling (Csp3-Csp) of natural α-amino acids and alkynes”, J. Org. Chem. 2010, 75, 783-788.

[20] Bi, H.-P; Chen, W.-W.; Liang, Y.-M.; Li, C.-J.* “A Novel Iron-Catalyzed Decarboxylative Csp3-Csp2 Coupling of Proline Derivatives and Naphthol”, Org. Lett. 2009, 11, 3246-3249.

[21] Chen, W.-W.; Nguyen, R. V.; Li, C.-J.* “Iron-Catalyzed Three-Component Coupling of Aldehyde, Alkyne and Amine under Neat Conditions in Air”, Tetrahedron Lett. 2009, 50, 2895-2898.

[22] Deng, G.;Chen, W.-W.; Li, C.-J.* “An Unusual Peroxide-Mediated Amination of Cycloalkanes with Nitroarenes”, Adv. Synth. Catal. 2009, 351, 353-356.

[23] Chen, W.-W.; Xu, M.-H.*; Lin, G.-Q.* “Unusual heterochiral crystallization tendency of 3-arylphthalide compounds in non-racemic solution: reinvestigation on asymmetric Ni-catalyzed tandem reaction of substituted o-halobenzaldehydes”, TetrahedronLett. 2007, 48, 7508-7511.

5. 获奖情况:

[1] 赛诺菲-中国科学院上海生命科学研究院优秀青年科技人才奖2017

[2] 中国科学院上海药物研究所“新星计划”2015

6. 代表性授权专利:

      [1]林国强,徐明华,陈雯雯,赵骞,周佩,史训龙,具有生物活性的联芳香类化合物,专利号:ZL200910049511.1

      [2]林国强,徐明华,陈雯雯,一种制备光学活性的轴手性联芳香类化合物的方法专利号:ZL200910049510.7

      [3] 林国强,张波,陈雯雯,孙兴文,李榕,徐明华,3-取代苯肽及其类似物的用途,专利号:ZL200810202967.2

联系方式:

Emailwenwen@shnu.edu.cn